The purpose of an orthosis is to unload, stabilise or guide the movement of muscles, bones or joints. It can be adjusted to permit controlled movements up to a predetermined limit (stop). It can also restrict the range of motion all the way to total immobilisation. The diversity of indications demands in-depth knowledge of the anatomical foundations, pathophysiological mechanisms and biomechanical principles. An overview of the aspects involved in fabricating a custom orthosis is provided according to the specific indication and the fitting levels. Participants also receive valuable patient care tips.